Zebra ZD421 Healthcare Mobile Printer

Clinicians need reliable technology to help them provide exceptional patient care. Healthcare tabletop printers need to be easy to set up, simple to operate, and intuitive to manage and maintain. The Zebra ZD421 is designed to integrate flawlessly into your existing healthcare system and increase speed and efficiency of your clinician’s daily processes. The ZD421 is a safe, secure, and simple option to enhance your clinician’s ability to provide excellent patient care.


peace-of-mind security

Protecting your health system is of utmost importance. Thats why the ZD421 can be configured easily via secure connections, makes it easy to identify vulnerabilities, and even block unauthorized access. 

hassle free

Get your printer up and running quickly and securely and benefit from uninterrupted and consistent printing with this fully integrated solution that will evolve along with your business needs.

One Place Management

With Zebra’s Printer Profile Manager Enterprise, you have the ability to easily manage, secure and troubleshoot your networked printers from one remote location. Manage one printer, a group of specific printers or all printers at any of your locations anywhere in the world.




Standard Features:

• Print methods: Thermal Transfer or Direct Thermal

• ZPL and EPL programming languages

• 5 status icon, 3 button user interface

• USB 2.0, USB Host

• Printer setup mobile app for Android & iOS via BLE (Bluetooth Low Energy 5) connection*

* BLE is intended for use with Zebra printer setup mobile app only

• Real Time Clock (RTC)

• OpenACCESS™ for easy media loading

• Dual-wall frame construction

• ENERGY STAR® certified

• ZebraDesigner Essentials

• PDF Direct

• Two-year standard warranty






Direct Thermal:

8.69 in. L x 6.98 in. W x 5.93 in. H

220.8 mm L x 177.5 mm W x 150.7 mm H


Thermal Transfer Roll:

10.5 in. L x 8.0 in. W x 7.44 in. H

267 mm L x 202 mm W x 189 mm H


Thermal Transfer Cartridge:

10.0 in. L x 8.0 in. W x 7.0 in. H

254 mm L x 202 mm W x 177 mm H




Direct Thermal: 2.98 lbs./1.35 kg

Thermal Transfer Roll: 4.52 lbs./2.05 kg

Thermal Transfer Cartridge: 5.0 lbs./2.3 kg




Operating System: Link-OS®

Resolution: 203 dpi/8 dots per mm / 300 dpi/12 dots per mm (optional)

Memory: 512 MB Flash; 256MB SDRAM / 64 MB user available non-volatile memory / 8 MB user available SDRAM


Maximum Print Width:

4.09 in./104 mm for 203 dpi

4.27 in./108 mm for 300 dpi

Cartridge: 4.09 in./104 mm for 203 and 300 dpi


Maximum Print Speed:

6 in./152 mm per second (203 dpi)

4 in./102 mm per second (300 dpi)


Media Sensors: Full width, moveable reflective/black mark sensor; multi-position transmissive/gap sensor


Firmware: ZPL II; EPL 2; XML; ZBI; PDF Direct


Media, Ribbon and Cartridge Characteristics


Label Length: Maximum: 39.0 in./991 mm / Minimum: 0.25 in./6.4 mm


Media Width

Direct Thermal: 0.585 in./15 mm to 4.25 in./108 mm

Thermal Transfer Roll: 0.585 in./15 mm to 4.41 in./ 112 mm

Thermal Transfer Cartridge: 0.585 in./15 mm to 4.65 in./118 mm


Media Roll Size

Maximum outer diameter: 5.00 in./127 mm

Core inner diameter: 0.5 in. (12.7 mm) and 1.0 in. (25.4 mm) standard, 1.5 in. (38.1), 2.0 in., (50.8 mm) and 3.0 in. (76.2 mm) using optional adapters


Media Thickness: 0.003 in. (0.08 mm) min.; 0.0075 in. (0.19 mm) max.


Media Types:  Roll-fed or fan-fold, die cut or continuous with or without black mark, tag stock, continuous receipt paper, and wristbands


Ribbon Outside Diameter 2.6 in./66 mm (300 m); 1.34 in./34 mm (74 m)


Ribbon Standard Length

Roll: 984 ft. (300 m); 243 ft. (74 m)

Cartridge: 243 ft. (74 m)


Ribbon Ratio

1:4 ribbon to media (300 m)

1:1 ribbon to media (74 m)


Ribbon Width

Roll: 1.33 in./33.8 mm — 4.3 in./109.2 mm

Cartridge: 4.3 in./109.2 mm


Ribbon Core I.D.: 300 meter ribbon 1 in./25.4 mm / 74 meter ribbon 0.5 in./12.7 mm


Operating Characteristics


Operating Temp.: 40° to 105° F/4.4° to 41° C

Storage Temp.: -40° to 140° F/-40° to 60° C


Operating Humidity: 10% to 90% non-condensing

Storage Humidity: 5% to 95% non-condensing

Electrical: Auto-detectable (PFC Compliant) 100-240VAC, 50-60Hz; ENERGY STAR certified; Energy Efficiency Level VI certified; optional 2750 mAh battery; Healthcare models include IEC60601-1 certified power supply




Media Handling: 

Dispenser/Peeler: label peel and present with label present sensor (field installable)

Cutter (field installable)


Communications: Field installable: Ethernet 10/100, 802.11ac Wi-Fi and Bluetooth 4.1 (dual radio); Serial RS-232 auto-sensing, DB-9 Factory installed: Ethernet 10/100, 802.11ac Wi-Fi and Bluetooth 4.1 (dual radio)




Battery: Provides power to the printer to support a full shift of printing at maximum print speed; supports all connectivity and media handling options

Carrying Case: Carrying case with shoulder strap and handles makes it easy to bring your desktop printer and battery to the point of application

Keyboard Display Unit: Zebra Keyboard Display Unit (ZKDU) unit for stand-alone printing solutions

Mounting Plate: Secure ZD Series printers to countertops or shelves

Enclosed Power Supply: Attached power supply accessory for cord-free installation




Bar Code Ratios: 2:1 and 3:1

1D Bar Codes: Code 11, Code 39, Code 93, Code 128, ISBT-128, UPC-A, UPC-E, EAN-8, EAN-13, UPC and EAN 2-or 5-digit extensions, Plessey, Postnet, Standard 2-of-5, Industrial 2-of-5, Interleaved 2-of-5, Logmars, MSI, Codabar and Planet Code


2D Bar Codes: Codablock, PDF417, Code 49, DataMatrix, MaxiCode, QR Code, MicroPDF, Aztec


Fonts and Graphics: 16 resident expandable ZPL II bitmap fonts, two resident scalable ZPL fonts, five resident expandable EPL2 fonts, native open-type font support, Unicode compliant. China units include SimSun simplified Chinese font